Per-Ingvar Branemark, M.D., Ph.D., Swedish orthopedic surgeon and researcher, passed away on December 20, 2014 in his hometown of Gothenburg, Sweden. In 1952, Dr. Branemark and his associates were engaged in research studying the physiology of bone healing. A component of the study involved implanting titanium cylinders into the bones of rabbits. When they attempted to remove the devices, they discovered the bone had fused to the metal preventing their removal. Dr. Branemark then made the revolutionary shift of paradigm, and envisioned using titanium implants to replace the roots of teeth. The first patient to benefit from this new concept of Dr. Branemark’s was a man born with a severe facial deformity and no teeth. Because of the bone deformity the patient was unable to wear dentures. Dr Branemark placed four titanium cylinders into the patient’s jaw, which he was able to utilize to retain a denture and function until his death forty years later. Over the subsequent decades, Dr Branemark remained closely involved in the research and development of dental implants, and was personally involved in the transformation of many patients’ lives. Millions of dental implants have been placed worldwide and this has become the standard of care for permanent tooth replacement. Dr. Branemark was awarded the European Inventor Award for Lifetime Achievement, The Swedish Society of Medicine’s Soderberg Prize, and the Swedish Engineering Academy’s medal for technical innovation. His legacy of innovation will bless mankind for generations to come.